Starch-based magnetic nanocomposite for targeted delivery of hydrophilic bioactives as anticancer strategy

Alexandre C.C. Sousa; Adolfo I.B. Romo; Raimundo R. Almeida; Aiêrta C.C. Silva; Lillian M.U. Fechine; Débora H.A. Brito; Rafael M. Freire; Daniel P. Pinheiro; Larissa M.R. Silva; Otília D.L. Pessoa; Juliano C. Denardin; Claudia Pessoa; Nágila M.P.S. Ricardo

doi:10.1016/j.carbpol.2021.118017

Starch-based magnetic nanocomposite for targeted delivery of hydrophilic bioactives as anticancer strategy

Alexandre C.C. Sousa
, Adolfo I.B. Romo
, Raimundo R. Almeida
, Aiêrta C.C. Silva
, Lillian M.U. Fechine
, Débora H.A. Brito
, Rafael M. Freire
, Daniel P. Pinheiro
, Larissa M.R. Silva
, Otília D.L. Pessoa
, Juliano C. Denardin
, Claudia Pessoa
, Nágila M.P.S. Ricardo

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

31 Citas (Scopus)

Resumen

Magnetic nanocomposites were synthesized for the targeted delivery of hydrophilic bioactives through guidance generated by a magnetic field. Superparamagnetic iron oxide nanoparticles (SPIONs) were used to generate hydroxyethyl starch magnetic nanocapsules (HES MNCs). This synthesis allowed the co-encapsulation of oncocalyxone A (onco A) and surface-modified magnetite nanoparticles (Fe₃O₄@citrate) into the same nanostructure. The synthesized nanocapsules exhibited a core-shell morphology, with an average diameter of 143 nm. This nanocomposite showed potential anticancer activity (IC₅₀) against four human tumor cell lines: glioblastoma SNB-19 (1.010 μgmL⁻¹), colon carcinoma HCT-116 (2.675 μgmL⁻¹), prostate PC3 (4.868 μgmL⁻¹), and leukemia HL-60 (2.166 μgmL⁻¹). Additionally, in vivo toxicity and locomotor activity were evaluated in a zebrafish (Danio rerio) model. The nanocomposite exhibited in vitro cytotoxicity, prolonged drug release profile and also responded to an applied magnetic field, representing a versatile compound with perspectives for highest concentration of different hydrophilic bioactives in a target tissue through magnetic vectorization.

Idioma original	Inglés
Número de artículo	118017
Publicación	Carbohydrate Polymers
Volumen	264
DOI	https://doi.org/10.1016/j.carbpol.2021.118017
Estado	Publicada - 15 jul. 2021
Publicado de forma externa	Sí

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Sousa, A. C. C., Romo, A. I. B., Almeida, R. R., Silva, A. C. C., Fechine, L. M. U., Brito, D. H. A., Freire, R. M., Pinheiro, D. P., Silva, L. M. R., Pessoa, O. D. L., Denardin, J. C., Pessoa, C., & Ricardo, N. M. P. S. (2021). Starch-based magnetic nanocomposite for targeted delivery of hydrophilic bioactives as anticancer strategy. Carbohydrate Polymers, 264, Artículo 118017. https://doi.org/10.1016/j.carbpol.2021.118017

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title = "Starch-based magnetic nanocomposite for targeted delivery of hydrophilic bioactives as anticancer strategy",

abstract = "Magnetic nanocomposites were synthesized for the targeted delivery of hydrophilic bioactives through guidance generated by a magnetic field. Superparamagnetic iron oxide nanoparticles (SPIONs) were used to generate hydroxyethyl starch magnetic nanocapsules (HES MNCs). This synthesis allowed the co-encapsulation of oncocalyxone A (onco A) and surface-modified magnetite nanoparticles (Fe3O4@citrate) into the same nanostructure. The synthesized nanocapsules exhibited a core-shell morphology, with an average diameter of 143 nm. This nanocomposite showed potential anticancer activity (IC50) against four human tumor cell lines: glioblastoma SNB-19 (1.010 μgmL−1), colon carcinoma HCT-116 (2.675 μgmL−1), prostate PC3 (4.868 μgmL−1), and leukemia HL-60 (2.166 μgmL−1). Additionally, in vivo toxicity and locomotor activity were evaluated in a zebrafish (Danio rerio) model. The nanocomposite exhibited in vitro cytotoxicity, prolonged drug release profile and also responded to an applied magnetic field, representing a versatile compound with perspectives for highest concentration of different hydrophilic bioactives in a target tissue through magnetic vectorization.",

keywords = "Drug delivery vehicles, Magnetic nanocarriers, Nanocapsules, Oncocalyxone A, Prolonged release, SPIONs",

author = "Sousa, \{Alexandre C.C.\} and Romo, \{Adolfo I.B.\} and Almeida, \{Raimundo R.\} and Silva, \{Ai{\^e}rta C.C.\} and Fechine, \{Lillian M.U.\} and Brito, \{D{\'e}bora H.A.\} and Freire, \{Rafael M.\} and Pinheiro, \{Daniel P.\} and Silva, \{Larissa M.R.\} and Pessoa, \{Ot{\'i}lia D.L.\} and Denardin, \{Juliano C.\} and Claudia Pessoa and Ricardo, \{N{\'a}gila M.P.S.\}",

note = "Publisher Copyright: {\textcopyright} 2021 Elsevier Ltd",

year = "2021",

month = jul,

day = "15",

doi = "10.1016/j.carbpol.2021.118017",

language = "English",

volume = "264",

journal = "Carbohydrate Polymers",

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AU - Sousa, Alexandre C.C.

AU - Romo, Adolfo I.B.

AU - Almeida, Raimundo R.

AU - Silva, Aiêrta C.C.

AU - Fechine, Lillian M.U.

AU - Brito, Débora H.A.

AU - Freire, Rafael M.

AU - Pinheiro, Daniel P.

AU - Silva, Larissa M.R.

AU - Pessoa, Otília D.L.

AU - Denardin, Juliano C.

AU - Pessoa, Claudia

AU - Ricardo, Nágila M.P.S.

PY - 2021/7/15

Y1 - 2021/7/15

N2 - Magnetic nanocomposites were synthesized for the targeted delivery of hydrophilic bioactives through guidance generated by a magnetic field. Superparamagnetic iron oxide nanoparticles (SPIONs) were used to generate hydroxyethyl starch magnetic nanocapsules (HES MNCs). This synthesis allowed the co-encapsulation of oncocalyxone A (onco A) and surface-modified magnetite nanoparticles (Fe3O4@citrate) into the same nanostructure. The synthesized nanocapsules exhibited a core-shell morphology, with an average diameter of 143 nm. This nanocomposite showed potential anticancer activity (IC50) against four human tumor cell lines: glioblastoma SNB-19 (1.010 μgmL−1), colon carcinoma HCT-116 (2.675 μgmL−1), prostate PC3 (4.868 μgmL−1), and leukemia HL-60 (2.166 μgmL−1). Additionally, in vivo toxicity and locomotor activity were evaluated in a zebrafish (Danio rerio) model. The nanocomposite exhibited in vitro cytotoxicity, prolonged drug release profile and also responded to an applied magnetic field, representing a versatile compound with perspectives for highest concentration of different hydrophilic bioactives in a target tissue through magnetic vectorization.

AB - Magnetic nanocomposites were synthesized for the targeted delivery of hydrophilic bioactives through guidance generated by a magnetic field. Superparamagnetic iron oxide nanoparticles (SPIONs) were used to generate hydroxyethyl starch magnetic nanocapsules (HES MNCs). This synthesis allowed the co-encapsulation of oncocalyxone A (onco A) and surface-modified magnetite nanoparticles (Fe3O4@citrate) into the same nanostructure. The synthesized nanocapsules exhibited a core-shell morphology, with an average diameter of 143 nm. This nanocomposite showed potential anticancer activity (IC50) against four human tumor cell lines: glioblastoma SNB-19 (1.010 μgmL−1), colon carcinoma HCT-116 (2.675 μgmL−1), prostate PC3 (4.868 μgmL−1), and leukemia HL-60 (2.166 μgmL−1). Additionally, in vivo toxicity and locomotor activity were evaluated in a zebrafish (Danio rerio) model. The nanocomposite exhibited in vitro cytotoxicity, prolonged drug release profile and also responded to an applied magnetic field, representing a versatile compound with perspectives for highest concentration of different hydrophilic bioactives in a target tissue through magnetic vectorization.

KW - Drug delivery vehicles

KW - Magnetic nanocarriers

KW - Nanocapsules

KW - Oncocalyxone A

KW - Prolonged release

KW - SPIONs

UR - https://www.scopus.com/pages/publications/85103684716

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DO - 10.1016/j.carbpol.2021.118017

M3 - Article

C2 - 33910740

AN - SCOPUS:85103684716

SN - 0144-8617

VL - 264

JO - Carbohydrate Polymers

JF - Carbohydrate Polymers

M1 - 118017

ER -

Starch-based magnetic nanocomposite for targeted delivery of hydrophilic bioactives as anticancer strategy

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