Relativistic Structure-Activity Relationship of Cisplatin(II) Complexes

L. Alvarado-Soto; R. Ramirez-Tagle

doi:10.1134/S0022476620050030

Relativistic Structure-Activity Relationship of Cisplatin(II) Complexes

L. Alvarado-Soto
, R. Ramirez-Tagle

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

3 Citas (Scopus)

Resumen

Cytotoxic activities of cisplatin(II) complexes against cancer cell lines are studied using the relativistic structure-activity relationship analysis. Global reactivity descriptors based on the relativistic density functional theory are used. This work demonstrates the usefulness of the relativistic reactivity descriptors to predict the biological activity of the complexes studied.

Idioma original	Inglés
Páginas (desde-hasta)	688-693
Número de páginas	6
Publicación	Journal of Structural Chemistry
Volumen	61
N.º	5
DOI	https://doi.org/10.1134/S0022476620050030
Estado	Publicada - 1 may. 2020
Publicado de forma externa	Sí

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@article{809a37f4fd4c4448a8974828a491d425,

title = "Relativistic Structure-Activity Relationship of Cisplatin(II) Complexes",

abstract = "Cytotoxic activities of cisplatin(II) complexes against cancer cell lines are studied using the relativistic structure-activity relationship analysis. Global reactivity descriptors based on the relativistic density functional theory are used. This work demonstrates the usefulness of the relativistic reactivity descriptors to predict the biological activity of the complexes studied.",

keywords = "cisplatin(II) complexes, relativistic DFT structure-activity relationship",

author = "L. Alvarado-Soto and R. Ramirez-Tagle",

note = "Publisher Copyright: {\textcopyright} 2020, Pleiades Publishing, Ltd.",

year = "2020",

month = may,

day = "1",

doi = "10.1134/S0022476620050030",

language = "English",

volume = "61",

pages = "688--693",

journal = "Journal of Structural Chemistry",

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TY - JOUR

T1 - Relativistic Structure-Activity Relationship of Cisplatin(II) Complexes

AU - Alvarado-Soto, L.

AU - Ramirez-Tagle, R.

PY - 2020/5/1

Y1 - 2020/5/1

N2 - Cytotoxic activities of cisplatin(II) complexes against cancer cell lines are studied using the relativistic structure-activity relationship analysis. Global reactivity descriptors based on the relativistic density functional theory are used. This work demonstrates the usefulness of the relativistic reactivity descriptors to predict the biological activity of the complexes studied.

AB - Cytotoxic activities of cisplatin(II) complexes against cancer cell lines are studied using the relativistic structure-activity relationship analysis. Global reactivity descriptors based on the relativistic density functional theory are used. This work demonstrates the usefulness of the relativistic reactivity descriptors to predict the biological activity of the complexes studied.

KW - cisplatin(II) complexes

KW - relativistic DFT structure-activity relationship

UR - https://www.scopus.com/pages/publications/85089218751

U2 - 10.1134/S0022476620050030

DO - 10.1134/S0022476620050030

M3 - Article

AN - SCOPUS:85089218751

SN - 0022-4766

VL - 61

SP - 688

EP - 693

JO - Journal of Structural Chemistry

JF - Journal of Structural Chemistry

IS - 5

ER -

Relativistic Structure-Activity Relationship of Cisplatin(II) Complexes

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