Cancer and brassinosteroids: Mechanisms of action, SAR and future perspectives

Marcos Lorca; David Cabezas; Ileana Araque; Andrés Terán; Santiago Hernández; Marco Mellado; Luis Espinoza; Jaime Mella

doi:10.1016/j.steroids.2022.109153

Cancer and brassinosteroids: Mechanisms of action, SAR and future perspectives

Marcos Lorca
, David Cabezas
, Ileana Araque
, Andrés Terán
, Santiago Hernández
, Marco Mellado
, Luis Espinoza
, Jaime Mella

Universidad de Valparaíso
Universidad Técnico Federico Santa María

Producción científica: Contribución a una revista › Artículo de revisión › revisión exhaustiva

10 Citas (Scopus)

Resumen

Brassinosteroids are plant hormones whose main function is to stimulate plant growth. However, they have been studied for their biological applications in humans. Brassinosteroid compounds have displayed an important role in the study of cancer pathology and show potential for developing novel anticancer drugs. In this review we describe the relationship of brassinosteroids with cancer with focus on the last decade, the mechanisms of cytotoxic activity described to date, and a structure–activity relationship based on the available information.

Idioma original	Inglés
Número de artículo	109153
Publicación	Steroids
Volumen	190
DOI	https://doi.org/10.1016/j.steroids.2022.109153
Estado	Publicada - feb. 2023

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title = "Cancer and brassinosteroids: Mechanisms of action, SAR and future perspectives",

abstract = "Brassinosteroids are plant hormones whose main function is to stimulate plant growth. However, they have been studied for their biological applications in humans. Brassinosteroid compounds have displayed an important role in the study of cancer pathology and show potential for developing novel anticancer drugs. In this review we describe the relationship of brassinosteroids with cancer with focus on the last decade, the mechanisms of cytotoxic activity described to date, and a structure–activity relationship based on the available information.",

keywords = "Antitumor, Brassinolide, Brassinosteroid, Cancer, Epibrassinolide, SAR",

author = "Marcos Lorca and David Cabezas and Ileana Araque and Andr{\'e}s Ter{\'a}n and Santiago Hern{\'a}ndez and Marco Mellado and Luis Espinoza and Jaime Mella",

note = "Publisher Copyright: {\textcopyright} 2022 Elsevier Inc.",

year = "2023",

month = feb,

doi = "10.1016/j.steroids.2022.109153",

language = "English",

volume = "190",

journal = "Steroids",

issn = "0039-128X",

}

TY - JOUR

T1 - Cancer and brassinosteroids

T2 - Mechanisms of action, SAR and future perspectives

AU - Lorca, Marcos

AU - Cabezas, David

AU - Araque, Ileana

AU - Terán, Andrés

AU - Hernández, Santiago

AU - Mellado, Marco

AU - Espinoza, Luis

AU - Mella, Jaime

PY - 2023/2

Y1 - 2023/2

N2 - Brassinosteroids are plant hormones whose main function is to stimulate plant growth. However, they have been studied for their biological applications in humans. Brassinosteroid compounds have displayed an important role in the study of cancer pathology and show potential for developing novel anticancer drugs. In this review we describe the relationship of brassinosteroids with cancer with focus on the last decade, the mechanisms of cytotoxic activity described to date, and a structure–activity relationship based on the available information.

AB - Brassinosteroids are plant hormones whose main function is to stimulate plant growth. However, they have been studied for their biological applications in humans. Brassinosteroid compounds have displayed an important role in the study of cancer pathology and show potential for developing novel anticancer drugs. In this review we describe the relationship of brassinosteroids with cancer with focus on the last decade, the mechanisms of cytotoxic activity described to date, and a structure–activity relationship based on the available information.

KW - Antitumor

KW - Brassinolide

KW - Brassinosteroid

KW - Cancer

KW - Epibrassinolide

KW - SAR

UR - https://www.scopus.com/pages/publications/85145593456

U2 - 10.1016/j.steroids.2022.109153

DO - 10.1016/j.steroids.2022.109153

M3 - Review article

C2 - 36481216

AN - SCOPUS:85145593456

SN - 0039-128X

VL - 190

JO - Steroids

JF - Steroids

M1 - 109153

ER -

Cancer and brassinosteroids: Mechanisms of action, SAR and future perspectives

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