Synthesis, chemical identification, drug release and docking studies of the amlodipine-chitosan nanobiopolymer composite

RODRIGO RAMIREZ-TAGLE; GUILLERMO SALGADO-MORAN; DAVID MENDEZ-LUNA; JOSÉ CORREABASURTO; WILSON CARDONA VILLADA; LORENA GERLI CANDIA; LUIS H. MENDOZA-HUIZAR

doi:10.4067/S0717-97072021000105063

Synthesis, chemical identification, drug release and docking studies of the amlodipine-chitosan nanobiopolymer composite

RODRIGO RAMIREZ-TAGLE
, GUILLERMO SALGADO-MORAN
, DAVID MENDEZ-LUNA
, JOSÉ CORREABASURTO
, WILSON CARDONA VILLADA
, LORENA GERLI CANDIA
, LUIS H. MENDOZA-HUIZAR

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

A new amlodipine-chitosan nanocomposite was built using amlodipine nanoparticles as primary scaffolds by spontaneous emulsification, and its complete elucidation was performed by using several spectrometric techniques. Our results indicate that the amlodipine-chitosan nanocomposite has better solubility than amlodipine at pH 7.4 with a nearly all the drug substance dissolved (97%) by the final time-point measured. The docking study support the existence of intermolecular interactions are established between amlodipine and chitosan.

Original language	English
Pages (from-to)	5063-5066
Number of pages	4
Journal	Journal of the Chilean Chemical Society
Volume	65
Issue number	1
DOIs	https://doi.org/10.4067/S0717-97072021000105063
State	Published - Jan 2021
Externally published	Yes

Keywords

Amlodipine
Chitosan
Docking studies
Drug-release properties
Nanocomposite

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10.4067/S0717-97072021000105063

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RAMIREZ-TAGLE, RODRIGO., SALGADO-MORAN, GUILLERMO., MENDEZ-LUNA, DAVID., CORREABASURTO, JOSÉ., VILLADA, WILSON. CARDONA., CANDIA, LORENA. GERLI., & MENDOZA-HUIZAR, LUIS. H. (2021). Synthesis, chemical identification, drug release and docking studies of the amlodipine-chitosan nanobiopolymer composite. Journal of the Chilean Chemical Society, 65(1), 5063-5066. https://doi.org/10.4067/S0717-97072021000105063

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title = "Synthesis, chemical identification, drug release and docking studies of the amlodipine-chitosan nanobiopolymer composite",

abstract = "A new amlodipine-chitosan nanocomposite was built using amlodipine nanoparticles as primary scaffolds by spontaneous emulsification, and its complete elucidation was performed by using several spectrometric techniques. Our results indicate that the amlodipine-chitosan nanocomposite has better solubility than amlodipine at pH 7.4 with a nearly all the drug substance dissolved (97\%) by the final time-point measured. The docking study support the existence of intermolecular interactions are established between amlodipine and chitosan.",

keywords = "Amlodipine, Chitosan, Docking studies, Drug-release properties, Nanocomposite",

author = "RODRIGO RAMIREZ-TAGLE and GUILLERMO SALGADO-MORAN and DAVID MENDEZ-LUNA and JOS{\'E} CORREABASURTO and VILLADA, \{WILSON CARDONA\} and CANDIA, \{LORENA GERLI\} and MENDOZA-HUIZAR, \{LUIS H.\}",

year = "2021",

month = jan,

doi = "10.4067/S0717-97072021000105063",

language = "English",

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RAMIREZ-TAGLE, RODRIGO, SALGADO-MORAN, GUILLERMO, MENDEZ-LUNA, DAVID, CORREABASURTO, JOSÉ, VILLADA, WILSONCARDONA, CANDIA, LORENAGERLI & MENDOZA-HUIZAR, LUISH 2021, 'Synthesis, chemical identification, drug release and docking studies of the amlodipine-chitosan nanobiopolymer composite', Journal of the Chilean Chemical Society, vol. 65, no. 1, pp. 5063-5066. https://doi.org/10.4067/S0717-97072021000105063

TY - JOUR

T1 - Synthesis, chemical identification, drug release and docking studies of the amlodipine-chitosan nanobiopolymer composite

AU - RAMIREZ-TAGLE, RODRIGO

AU - SALGADO-MORAN, GUILLERMO

AU - MENDEZ-LUNA, DAVID

AU - CORREABASURTO, JOSÉ

AU - VILLADA, WILSON CARDONA

AU - CANDIA, LORENA GERLI

AU - MENDOZA-HUIZAR, LUIS H.

PY - 2021/1

Y1 - 2021/1

N2 - A new amlodipine-chitosan nanocomposite was built using amlodipine nanoparticles as primary scaffolds by spontaneous emulsification, and its complete elucidation was performed by using several spectrometric techniques. Our results indicate that the amlodipine-chitosan nanocomposite has better solubility than amlodipine at pH 7.4 with a nearly all the drug substance dissolved (97%) by the final time-point measured. The docking study support the existence of intermolecular interactions are established between amlodipine and chitosan.

AB - A new amlodipine-chitosan nanocomposite was built using amlodipine nanoparticles as primary scaffolds by spontaneous emulsification, and its complete elucidation was performed by using several spectrometric techniques. Our results indicate that the amlodipine-chitosan nanocomposite has better solubility than amlodipine at pH 7.4 with a nearly all the drug substance dissolved (97%) by the final time-point measured. The docking study support the existence of intermolecular interactions are established between amlodipine and chitosan.

KW - Amlodipine

KW - Chitosan

KW - Docking studies

KW - Drug-release properties

KW - Nanocomposite

UR - https://www.scopus.com/pages/publications/85102856855

U2 - 10.4067/S0717-97072021000105063

DO - 10.4067/S0717-97072021000105063

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AN - SCOPUS:85102856855

SN - 0717-9324

VL - 65

SP - 5063

EP - 5066

JO - Journal of the Chilean Chemical Society

JF - Journal of the Chilean Chemical Society

IS - 1

ER -

Synthesis, chemical identification, drug release and docking studies of the amlodipine-chitosan nanobiopolymer composite

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Keywords

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