Starch-based magnetic nanocomposite for targeted delivery of hydrophilic bioactives as anticancer strategy

Alexandre C.C. Sousa; Adolfo I.B. Romo; Raimundo R. Almeida; Aiêrta C.C. Silva; Lillian M.U. Fechine; Débora H.A. Brito; Rafael M. Freire; Daniel P. Pinheiro; Larissa M.R. Silva; Otília D.L. Pessoa; Juliano C. Denardin; Claudia Pessoa; Nágila M.P.S. Ricardo

doi:10.1016/j.carbpol.2021.118017

Starch-based magnetic nanocomposite for targeted delivery of hydrophilic bioactives as anticancer strategy

Alexandre C.C. Sousa
, Adolfo I.B. Romo
, Raimundo R. Almeida
, Aiêrta C.C. Silva
, Lillian M.U. Fechine
, Débora H.A. Brito
, Rafael M. Freire
, Daniel P. Pinheiro
, Larissa M.R. Silva
, Otília D.L. Pessoa
, Juliano C. Denardin
, Claudia Pessoa
, Nágila M.P.S. Ricardo

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

Magnetic nanocomposites were synthesized for the targeted delivery of hydrophilic bioactives through guidance generated by a magnetic field. Superparamagnetic iron oxide nanoparticles (SPIONs) were used to generate hydroxyethyl starch magnetic nanocapsules (HES MNCs). This synthesis allowed the co-encapsulation of oncocalyxone A (onco A) and surface-modified magnetite nanoparticles (Fe₃O₄@citrate) into the same nanostructure. The synthesized nanocapsules exhibited a core-shell morphology, with an average diameter of 143 nm. This nanocomposite showed potential anticancer activity (IC₅₀) against four human tumor cell lines: glioblastoma SNB-19 (1.010 μgmL⁻¹), colon carcinoma HCT-116 (2.675 μgmL⁻¹), prostate PC3 (4.868 μgmL⁻¹), and leukemia HL-60 (2.166 μgmL⁻¹). Additionally, in vivo toxicity and locomotor activity were evaluated in a zebrafish (Danio rerio) model. The nanocomposite exhibited in vitro cytotoxicity, prolonged drug release profile and also responded to an applied magnetic field, representing a versatile compound with perspectives for highest concentration of different hydrophilic bioactives in a target tissue through magnetic vectorization.

Original language	English
Article number	118017
Journal	Carbohydrate Polymers
Volume	264
DOIs	https://doi.org/10.1016/j.carbpol.2021.118017
State	Published - 15 Jul 2021
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Drug delivery vehicles
Magnetic nanocarriers
Nanocapsules
Oncocalyxone A
Prolonged release
SPIONs

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10.1016/j.carbpol.2021.118017

Cite this

Sousa, A. C. C., Romo, A. I. B., Almeida, R. R., Silva, A. C. C., Fechine, L. M. U., Brito, D. H. A., Freire, R. M., Pinheiro, D. P., Silva, L. M. R., Pessoa, O. D. L., Denardin, J. C., Pessoa, C., & Ricardo, N. M. P. S. (2021). Starch-based magnetic nanocomposite for targeted delivery of hydrophilic bioactives as anticancer strategy. Carbohydrate Polymers, 264, Article 118017. https://doi.org/10.1016/j.carbpol.2021.118017

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title = "Starch-based magnetic nanocomposite for targeted delivery of hydrophilic bioactives as anticancer strategy",

abstract = "Magnetic nanocomposites were synthesized for the targeted delivery of hydrophilic bioactives through guidance generated by a magnetic field. Superparamagnetic iron oxide nanoparticles (SPIONs) were used to generate hydroxyethyl starch magnetic nanocapsules (HES MNCs). This synthesis allowed the co-encapsulation of oncocalyxone A (onco A) and surface-modified magnetite nanoparticles (Fe3O4@citrate) into the same nanostructure. The synthesized nanocapsules exhibited a core-shell morphology, with an average diameter of 143 nm. This nanocomposite showed potential anticancer activity (IC50) against four human tumor cell lines: glioblastoma SNB-19 (1.010 μgmL−1), colon carcinoma HCT-116 (2.675 μgmL−1), prostate PC3 (4.868 μgmL−1), and leukemia HL-60 (2.166 μgmL−1). Additionally, in vivo toxicity and locomotor activity were evaluated in a zebrafish (Danio rerio) model. The nanocomposite exhibited in vitro cytotoxicity, prolonged drug release profile and also responded to an applied magnetic field, representing a versatile compound with perspectives for highest concentration of different hydrophilic bioactives in a target tissue through magnetic vectorization.",

keywords = "Drug delivery vehicles, Magnetic nanocarriers, Nanocapsules, Oncocalyxone A, Prolonged release, SPIONs",

author = "Sousa, \{Alexandre C.C.\} and Romo, \{Adolfo I.B.\} and Almeida, \{Raimundo R.\} and Silva, \{Ai{\^e}rta C.C.\} and Fechine, \{Lillian M.U.\} and Brito, \{D{\'e}bora H.A.\} and Freire, \{Rafael M.\} and Pinheiro, \{Daniel P.\} and Silva, \{Larissa M.R.\} and Pessoa, \{Ot{\'i}lia D.L.\} and Denardin, \{Juliano C.\} and Claudia Pessoa and Ricardo, \{N{\'a}gila M.P.S.\}",

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doi = "10.1016/j.carbpol.2021.118017",

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AU - Sousa, Alexandre C.C.

AU - Romo, Adolfo I.B.

AU - Almeida, Raimundo R.

AU - Silva, Aiêrta C.C.

AU - Fechine, Lillian M.U.

AU - Brito, Débora H.A.

AU - Freire, Rafael M.

AU - Pinheiro, Daniel P.

AU - Silva, Larissa M.R.

AU - Pessoa, Otília D.L.

AU - Denardin, Juliano C.

AU - Pessoa, Claudia

AU - Ricardo, Nágila M.P.S.

PY - 2021/7/15

Y1 - 2021/7/15

N2 - Magnetic nanocomposites were synthesized for the targeted delivery of hydrophilic bioactives through guidance generated by a magnetic field. Superparamagnetic iron oxide nanoparticles (SPIONs) were used to generate hydroxyethyl starch magnetic nanocapsules (HES MNCs). This synthesis allowed the co-encapsulation of oncocalyxone A (onco A) and surface-modified magnetite nanoparticles (Fe3O4@citrate) into the same nanostructure. The synthesized nanocapsules exhibited a core-shell morphology, with an average diameter of 143 nm. This nanocomposite showed potential anticancer activity (IC50) against four human tumor cell lines: glioblastoma SNB-19 (1.010 μgmL−1), colon carcinoma HCT-116 (2.675 μgmL−1), prostate PC3 (4.868 μgmL−1), and leukemia HL-60 (2.166 μgmL−1). Additionally, in vivo toxicity and locomotor activity were evaluated in a zebrafish (Danio rerio) model. The nanocomposite exhibited in vitro cytotoxicity, prolonged drug release profile and also responded to an applied magnetic field, representing a versatile compound with perspectives for highest concentration of different hydrophilic bioactives in a target tissue through magnetic vectorization.

AB - Magnetic nanocomposites were synthesized for the targeted delivery of hydrophilic bioactives through guidance generated by a magnetic field. Superparamagnetic iron oxide nanoparticles (SPIONs) were used to generate hydroxyethyl starch magnetic nanocapsules (HES MNCs). This synthesis allowed the co-encapsulation of oncocalyxone A (onco A) and surface-modified magnetite nanoparticles (Fe3O4@citrate) into the same nanostructure. The synthesized nanocapsules exhibited a core-shell morphology, with an average diameter of 143 nm. This nanocomposite showed potential anticancer activity (IC50) against four human tumor cell lines: glioblastoma SNB-19 (1.010 μgmL−1), colon carcinoma HCT-116 (2.675 μgmL−1), prostate PC3 (4.868 μgmL−1), and leukemia HL-60 (2.166 μgmL−1). Additionally, in vivo toxicity and locomotor activity were evaluated in a zebrafish (Danio rerio) model. The nanocomposite exhibited in vitro cytotoxicity, prolonged drug release profile and also responded to an applied magnetic field, representing a versatile compound with perspectives for highest concentration of different hydrophilic bioactives in a target tissue through magnetic vectorization.

KW - Drug delivery vehicles

KW - Magnetic nanocarriers

KW - Nanocapsules

KW - Oncocalyxone A

KW - Prolonged release

KW - SPIONs

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AN - SCOPUS:85103684716

SN - 0144-8617

VL - 264

JO - Carbohydrate Polymers

JF - Carbohydrate Polymers

M1 - 118017

ER -

Starch-based magnetic nanocomposite for targeted delivery of hydrophilic bioactives as anticancer strategy

Abstract

UN SDGs

Keywords

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