Sedative effects of latexes obtained from some Lactuca L. species growing in Turkey

Selen Ilgün; Esra Küpeli Akkol; Mert Ilhan; Derya Çiçek Polat; Ayse Baldemir Kılıç; Maksut Coşkun; Eduardo Sobarzo-Sánchez

doi:10.3390/molecules25071587

Sedative effects of latexes obtained from some Lactuca L. species growing in Turkey

Selen Ilgün
, Esra Küpeli Akkol
, Mert Ilhan
, Derya Çiçek Polat
, Ayse Baldemir Kılıç
, Maksut Coşkun
, Eduardo Sobarzo-Sánchez

Universidad Central de Chile

Erciyes University
Gazi University
Van Yüzüncü Yıl University
Ankara University
University of Health Sciences
Instituto de Investigación e Innovación en Salud
Department of Organic Chemistry
Universidad Santiago de Compostela

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Lactuca L. species belong to the Asteraceae family and these plants are traditionally used for therapeutic purposes around the world. The dried milky latex of L. serriola is known as “lettuce oil” and is used as a sedative in Turkey. This study aimed to evaluate the sedative effects and analyze the chemical compositions of latexes obtained from some Lactuca species growing in Turkey. The sedative effects were evaluated through various behavioral tests on mice. For this purpose, latexes were obtained from L. glareosa Boiss., L. viminea (L.) J. Presl and C. P, L. mulgedioides (Vis and Panćić) Boiss. and Kotschy ex. Boiss., L. saligna L., and L. serriola L. The latex from L. saligna showed the highest sedative effects, whilst L. serriola and L. viminea latexes also displayed significant sedative effects compared to the control group at a dose of 100 mg/kg. However, the latexes from L. glareosa and L. mulqedioides did not exhibit any sedative effects on mice. Characteristic sesquiterpene lactones (lactucin, lactucopicrin, 11,13β-dihydrolactucin, and 11,13β-dihydrolactucopicrin) were determined qualitatively and quantitatively by high-performance liquid chromatography (HPLC). Lactucin was identified as the main component.

Original language	English
Article number	1587
Journal	Molecules
Volume	25
Issue number	7
DOIs	https://doi.org/10.3390/molecules25071587
State	Published - 29 Mar 2020

Keywords

Asteraceae
HPLC
Lactuca
Sedative effect
Sesquiterpene lactone

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10.3390/molecules25071587

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@article{6170694c81c44b8094a6573443fffafb,

title = "Sedative effects of latexes obtained from some Lactuca L. species growing in Turkey",

abstract = "Lactuca L. species belong to the Asteraceae family and these plants are traditionally used for therapeutic purposes around the world. The dried milky latex of L. serriola is known as “lettuce oil” and is used as a sedative in Turkey. This study aimed to evaluate the sedative effects and analyze the chemical compositions of latexes obtained from some Lactuca species growing in Turkey. The sedative effects were evaluated through various behavioral tests on mice. For this purpose, latexes were obtained from L. glareosa Boiss., L. viminea (L.) J. Presl and C. P, L. mulgedioides (Vis and Pan{\'c}i{\'c}) Boiss. and Kotschy ex. Boiss., L. saligna L., and L. serriola L. The latex from L. saligna showed the highest sedative effects, whilst L. serriola and L. viminea latexes also displayed significant sedative effects compared to the control group at a dose of 100 mg/kg. However, the latexes from L. glareosa and L. mulqedioides did not exhibit any sedative effects on mice. Characteristic sesquiterpene lactones (lactucin, lactucopicrin, 11,13β-dihydrolactucin, and 11,13β-dihydrolactucopicrin) were determined qualitatively and quantitatively by high-performance liquid chromatography (HPLC). Lactucin was identified as the main component.",

keywords = "Asteraceae, HPLC, Lactuca, Sedative effect, Sesquiterpene lactone",

author = "Selen Ilg{\"u}n and Akkol, \{Esra K{\"u}peli\} and Mert Ilhan and Polat, \{Derya {\c C}i{\c c}ek\} and Kılı{\c c}, \{Ayse Baldemir\} and Maksut Co{\c s}kun and Eduardo Sobarzo-S{\'a}nchez",

note = "Publisher Copyright: {\textcopyright} 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).",

year = "2020",

month = mar,

day = "29",

doi = "10.3390/molecules25071587",

language = "English",

volume = "25",

journal = "Molecules",

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TY - JOUR

T1 - Sedative effects of latexes obtained from some Lactuca L. species growing in Turkey

AU - Ilgün, Selen

AU - Akkol, Esra Küpeli

AU - Ilhan, Mert

AU - Polat, Derya Çiçek

AU - Kılıç, Ayse Baldemir

AU - Coşkun, Maksut

AU - Sobarzo-Sánchez, Eduardo

N1 - Publisher Copyright: © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

PY - 2020/3/29

Y1 - 2020/3/29

N2 - Lactuca L. species belong to the Asteraceae family and these plants are traditionally used for therapeutic purposes around the world. The dried milky latex of L. serriola is known as “lettuce oil” and is used as a sedative in Turkey. This study aimed to evaluate the sedative effects and analyze the chemical compositions of latexes obtained from some Lactuca species growing in Turkey. The sedative effects were evaluated through various behavioral tests on mice. For this purpose, latexes were obtained from L. glareosa Boiss., L. viminea (L.) J. Presl and C. P, L. mulgedioides (Vis and Panćić) Boiss. and Kotschy ex. Boiss., L. saligna L., and L. serriola L. The latex from L. saligna showed the highest sedative effects, whilst L. serriola and L. viminea latexes also displayed significant sedative effects compared to the control group at a dose of 100 mg/kg. However, the latexes from L. glareosa and L. mulqedioides did not exhibit any sedative effects on mice. Characteristic sesquiterpene lactones (lactucin, lactucopicrin, 11,13β-dihydrolactucin, and 11,13β-dihydrolactucopicrin) were determined qualitatively and quantitatively by high-performance liquid chromatography (HPLC). Lactucin was identified as the main component.

AB - Lactuca L. species belong to the Asteraceae family and these plants are traditionally used for therapeutic purposes around the world. The dried milky latex of L. serriola is known as “lettuce oil” and is used as a sedative in Turkey. This study aimed to evaluate the sedative effects and analyze the chemical compositions of latexes obtained from some Lactuca species growing in Turkey. The sedative effects were evaluated through various behavioral tests on mice. For this purpose, latexes were obtained from L. glareosa Boiss., L. viminea (L.) J. Presl and C. P, L. mulgedioides (Vis and Panćić) Boiss. and Kotschy ex. Boiss., L. saligna L., and L. serriola L. The latex from L. saligna showed the highest sedative effects, whilst L. serriola and L. viminea latexes also displayed significant sedative effects compared to the control group at a dose of 100 mg/kg. However, the latexes from L. glareosa and L. mulqedioides did not exhibit any sedative effects on mice. Characteristic sesquiterpene lactones (lactucin, lactucopicrin, 11,13β-dihydrolactucin, and 11,13β-dihydrolactucopicrin) were determined qualitatively and quantitatively by high-performance liquid chromatography (HPLC). Lactucin was identified as the main component.

KW - Asteraceae

KW - HPLC

KW - Lactuca

KW - Sedative effect

KW - Sesquiterpene lactone

UR - https://www.scopus.com/pages/publications/85082731046

U2 - 10.3390/molecules25071587

DO - 10.3390/molecules25071587

M3 - Article

C2 - 32235622

AN - SCOPUS:85082731046

SN - 1420-3049

VL - 25

JO - Molecules

JF - Molecules

IS - 7

M1 - 1587

ER -

Sedative effects of latexes obtained from some Lactuca L. species growing in Turkey

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Keywords

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