TY - JOUR
T1 - Natural products in drug discovery
T2 - advances and opportunities
AU - the International Natural Product Sciences Taskforce
AU - Atanasov, Atanas G.
AU - Zotchev, Sergey B.
AU - Dirsch, Verena M.
AU - Orhan, Ilkay Erdogan
AU - Banach, Maciej
AU - Rollinger, Judith M.
AU - Barreca, Davide
AU - Weckwerth, Wolfram
AU - Bauer, Rudolf
AU - Bayer, Edward A.
AU - Majeed, Muhammed
AU - Bishayee, Anupam
AU - Bochkov, Valery
AU - Bonn, Günther K.
AU - Braidy, Nady
AU - Bucar, Franz
AU - Cifuentes, Alejandro
AU - D’Onofrio, Grazia
AU - Bodkin, Michael
AU - Diederich, Marc
AU - Dinkova-Kostova, Albena T.
AU - Efferth, Thomas
AU - El Bairi, Khalid
AU - Arkells, Nicolas
AU - Fan, Tai Ping
AU - Fiebich, Bernd L.
AU - Freissmuth, Michael
AU - Georgiev, Milen I.
AU - Gibbons, Simon
AU - Godfrey, Keith M.
AU - Gruber, Christian W.
AU - Heer, Jag
AU - Huber, Lukas A.
AU - Ibanez, Elena
AU - Kijjoa, Anake
AU - Kiss, Anna K.
AU - Lu, Aiping
AU - Macias, Francisco A.
AU - Miller, Mark J.S.
AU - Mocan, Andrei
AU - Müller, Rolf
AU - Nicoletti, Ferdinando
AU - Perry, George
AU - Pittalà, Valeria
AU - Rastrelli, Luca
AU - Ristow, Michael
AU - Russo, Gian Luigi
AU - Silva, Ana Sanches
AU - Schuster, Daniela
AU - Sobarzo-Sánchez, Eduardo
N1 - Publisher Copyright:
© 2021, Springer Nature Limited.
PY - 2021/3
Y1 - 2021/3
N2 - Natural products and their structural analogues have historically made a major contribution to pharmacotherapy, especially for cancer and infectious diseases. Nevertheless, natural products also present challenges for drug discovery, such as technical barriers to screening, isolation, characterization and optimization, which contributed to a decline in their pursuit by the pharmaceutical industry from the 1990s onwards. In recent years, several technological and scientific developments — including improved analytical tools, genome mining and engineering strategies, and microbial culturing advances — are addressing such challenges and opening up new opportunities. Consequently, interest in natural products as drug leads is being revitalized, particularly for tackling antimicrobial resistance. Here, we summarize recent technological developments that are enabling natural product-based drug discovery, highlight selected applications and discuss key opportunities.
AB - Natural products and their structural analogues have historically made a major contribution to pharmacotherapy, especially for cancer and infectious diseases. Nevertheless, natural products also present challenges for drug discovery, such as technical barriers to screening, isolation, characterization and optimization, which contributed to a decline in their pursuit by the pharmaceutical industry from the 1990s onwards. In recent years, several technological and scientific developments — including improved analytical tools, genome mining and engineering strategies, and microbial culturing advances — are addressing such challenges and opening up new opportunities. Consequently, interest in natural products as drug leads is being revitalized, particularly for tackling antimicrobial resistance. Here, we summarize recent technological developments that are enabling natural product-based drug discovery, highlight selected applications and discuss key opportunities.
UR - https://www.scopus.com/pages/publications/85099930912
U2 - 10.1038/s41573-020-00114-z
DO - 10.1038/s41573-020-00114-z
M3 - Review article
C2 - 33510482
AN - SCOPUS:85099930912
SN - 1474-1776
VL - 20
SP - 200
EP - 216
JO - Nature Reviews Drug Discovery
JF - Nature Reviews Drug Discovery
IS - 3
ER -
SDG 3 Good Health and Well-being
SDG 9 Industry, Innovation, and Infrastructure