Impact of dietary fiber fraction of chia seed supplementation on hepatic steatosis and other metabolic disturbances in a high-fat diet model

Metabolic dysfunction-associated steatotic liver disease (MASLD), characterized by hepatic triglyceride elevation is prevalent globally and often leads to significant consequences such as steatosis and hepatocarcinoma. In association with insulin resistance, oxidative stress, and inflammation, effective interventions are essential. Dietary fiber plays a crucial role in regulating these metabolic parameters. Chia (Salvia hispanica L.), a fiber-rich oilseed, is known for its high fiber content. This study assessed the impact of the fiber-rich fraction of partially defatted chia seeds (FFC) on hepatic steatosis and metabolic disturbances induced by a high-fat diet (HFD) in mice. Male C57BL/6J mice were fed either a control diet (CD) or HFD for 10 weeks, followed by FFC or oatmeal supplementation for an additional 4 weeks. FFC intake significantly reduced hepatic steatosis, lowered triglyceride and cholesterol levels, normalized plasma triglycerides, decreased oxidative stress, and attenuated inflammation. FFC has emerged as a promising candidate for managing hepatic steatosis.