TY - JOUR
T1 - Flavonoid biosynthetic pathways in plants
T2 - Versatile targets for metabolic engineering
AU - Nabavi, Seyed Mohammad
AU - Šamec, Dunja
AU - Tomczyk, Michał
AU - Milella, Luigi
AU - Russo, Daniela
AU - Habtemariam, Solomon
AU - Suntar, Ipek
AU - Rastrelli, Luca
AU - Daglia, Maria
AU - Xiao, Jianbo
AU - Giampieri, Francesca
AU - Battino, Maurizio
AU - Sobarzo-Sanchez, Eduardo
AU - Nabavi, Seyed Fazel
AU - Yousefi, Bahman
AU - Jeandet, Philippe
AU - Xu, Suowen
AU - Shirooie, Samira
N1 - Publisher Copyright:
© 2018 Elsevier Inc.
PY - 2020/1/1
Y1 - 2020/1/1
N2 - Plants, fungi, and microorganisms are equipped with biosynthesis machinery for producing thousands of secondary metabolites. These compounds have important functions in nature as a defence against predators or competitors as well as other ecological significances. The full utilization of these compounds for food, medicine, and other purposes requires a thorough understanding of their structures and the distinct biochemical pathways of their production in cellular systems. In this review, flavonoids as classical examples of secondary metabolites are employed to highlight recent advances in understanding how valuable compounds can be regulated at various levels. With extensive diversity in their chemistry and pharmacology, understanding the metabolic engineering of flavonoids now allows us to fine-tune the eliciting of their production, accumulation, and extraction from living systems. More specifically, recent advances in the shikimic acid and acetate biosynthetic pathways of flavonoids production from metabolic engineering point of view, from genes expression to multiple principles of regulation, are addressed. Specific examples of plants and microorganisms as the sources of flavonoids-based compounds with particular emphasis on therapeutic applications are also discussed.
AB - Plants, fungi, and microorganisms are equipped with biosynthesis machinery for producing thousands of secondary metabolites. These compounds have important functions in nature as a defence against predators or competitors as well as other ecological significances. The full utilization of these compounds for food, medicine, and other purposes requires a thorough understanding of their structures and the distinct biochemical pathways of their production in cellular systems. In this review, flavonoids as classical examples of secondary metabolites are employed to highlight recent advances in understanding how valuable compounds can be regulated at various levels. With extensive diversity in their chemistry and pharmacology, understanding the metabolic engineering of flavonoids now allows us to fine-tune the eliciting of their production, accumulation, and extraction from living systems. More specifically, recent advances in the shikimic acid and acetate biosynthetic pathways of flavonoids production from metabolic engineering point of view, from genes expression to multiple principles of regulation, are addressed. Specific examples of plants and microorganisms as the sources of flavonoids-based compounds with particular emphasis on therapeutic applications are also discussed.
KW - Acetate
KW - Flavonoids
KW - Metabolic engineering
KW - Shikimic acid
UR - https://www.scopus.com/pages/publications/85057045755
U2 - 10.1016/j.biotechadv.2018.11.005
DO - 10.1016/j.biotechadv.2018.11.005
M3 - Review article
C2 - 30458225
AN - SCOPUS:85057045755
SN - 0734-9750
VL - 38
JO - Biotechnology Advances
JF - Biotechnology Advances
M1 - 107316
ER -