Cytotoxic Effect of Puya chilensis Collected in Central Chile

César Echeverria-Echeverria; Aly Valderrama-Villarroel; Marcelo Ortega; Rodrigo A. Contreras; Gustavo E. Zúñiga; Leonor Alvarado-Soto; Rodrigo Ramírez-Tagle

doi:10.1177/1934578X221091671

Cytotoxic Effect of Puya chilensis Collected in Central Chile

César Echeverria-Echeverria
, Aly Valderrama-Villarroel
, Marcelo Ortega
, Rodrigo A. Contreras
, Gustavo E. Zúñiga
, Leonor Alvarado-Soto
, Rodrigo Ramírez-Tagle

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

This study sought to evaluate the pharmacological activity of metabolites isolated from the dried and lyophilized ethanol extracts as well as other solvent fractions of the currently endangered Puya chilensis Molina (Chagual) by analyzing their effects on a human hepatocellular carcinoma (HCC) cell line. We identified several active metabolites from Chagual extracts and two, in particular, carnosol, were found in all the prepared fractions. In addition, Chagual exhibited considerable cytotoxicity against the cancer cell line used in this study, with a half-maximal inhibitory concentration (IC₅₀) of 0.44 ± 0.11 and 0.27 ± 0.04 after a 72-hour treatment and, therefore, has the potential for further investigation as a source of candidate therapeutic agents.

Original language	English
Journal	Natural Product Communications
Volume	17
Issue number	4
DOIs	https://doi.org/10.1177/1934578X221091671
State	Published - Apr 2022
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

bioactive nutrients
human hepatocellular carcinoma
metabolites
Puya chilensis

Access to Document

10.1177/1934578X221091671

Cite this

@article{2fc6fda3aba946b4814972ac947829ec,

title = "Cytotoxic Effect of Puya chilensis Collected in Central Chile",

abstract = "This study sought to evaluate the pharmacological activity of metabolites isolated from the dried and lyophilized ethanol extracts as well as other solvent fractions of the currently endangered Puya chilensis Molina (Chagual) by analyzing their effects on a human hepatocellular carcinoma (HCC) cell line. We identified several active metabolites from Chagual extracts and two, in particular, carnosol, were found in all the prepared fractions. In addition, Chagual exhibited considerable cytotoxicity against the cancer cell line used in this study, with a half-maximal inhibitory concentration (IC50) of 0.44 ± 0.11 and 0.27 ± 0.04 after a 72-hour treatment and, therefore, has the potential for further investigation as a source of candidate therapeutic agents.",

keywords = "bioactive nutrients, human hepatocellular carcinoma, metabolites, Puya chilensis",

author = "C{\'e}sar Echeverria-Echeverria and Aly Valderrama-Villarroel and Marcelo Ortega and Contreras, \{Rodrigo A.\} and Z{\'u}{\~n}iga, \{Gustavo E.\} and Leonor Alvarado-Soto and Rodrigo Ram{\'i}rez-Tagle",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2022.",

year = "2022",

month = apr,

doi = "10.1177/1934578X221091671",

language = "English",

volume = "17",

journal = "Natural Product Communications",

issn = "1934-578X",

number = "4",

}

TY - JOUR

T1 - Cytotoxic Effect of Puya chilensis Collected in Central Chile

AU - Echeverria-Echeverria, César

AU - Valderrama-Villarroel, Aly

AU - Ortega, Marcelo

AU - Contreras, Rodrigo A.

AU - Zúñiga, Gustavo E.

AU - Alvarado-Soto, Leonor

AU - Ramírez-Tagle, Rodrigo

PY - 2022/4

Y1 - 2022/4

N2 - This study sought to evaluate the pharmacological activity of metabolites isolated from the dried and lyophilized ethanol extracts as well as other solvent fractions of the currently endangered Puya chilensis Molina (Chagual) by analyzing their effects on a human hepatocellular carcinoma (HCC) cell line. We identified several active metabolites from Chagual extracts and two, in particular, carnosol, were found in all the prepared fractions. In addition, Chagual exhibited considerable cytotoxicity against the cancer cell line used in this study, with a half-maximal inhibitory concentration (IC50) of 0.44 ± 0.11 and 0.27 ± 0.04 after a 72-hour treatment and, therefore, has the potential for further investigation as a source of candidate therapeutic agents.

AB - This study sought to evaluate the pharmacological activity of metabolites isolated from the dried and lyophilized ethanol extracts as well as other solvent fractions of the currently endangered Puya chilensis Molina (Chagual) by analyzing their effects on a human hepatocellular carcinoma (HCC) cell line. We identified several active metabolites from Chagual extracts and two, in particular, carnosol, were found in all the prepared fractions. In addition, Chagual exhibited considerable cytotoxicity against the cancer cell line used in this study, with a half-maximal inhibitory concentration (IC50) of 0.44 ± 0.11 and 0.27 ± 0.04 after a 72-hour treatment and, therefore, has the potential for further investigation as a source of candidate therapeutic agents.

KW - bioactive nutrients

KW - human hepatocellular carcinoma

KW - metabolites

KW - Puya chilensis

UR - https://www.scopus.com/pages/publications/85128757217

U2 - 10.1177/1934578X221091671

DO - 10.1177/1934578X221091671

M3 - Article

AN - SCOPUS:85128757217

SN - 1934-578X

VL - 17

JO - Natural Product Communications

JF - Natural Product Communications

IS - 4

ER -

Cytotoxic Effect of Puya chilensis Collected in Central Chile

Abstract

UN SDGs

Keywords

Access to Document

Other files and links

Fingerprint

Cite this