Personal profile
Personal profile
Marco Mellado obtained his degree as a Chemistry and Science Teacher from the Universidad de Playa Ancha de Ciencias de la Educación, where he was recognized as the best graduate of his class. He later completed a Master of Science in Chemistry at the Universidad Técnica Federico Santa María, where he focused his thesis on Natural Products. He continued his training with a Ph.D. in Chemistry (UTFSM–Universidad de Valparaíso), oriented toward the rational design of bioactive compounds through chemical synthesis and computational tools (molecular docking and QSAR). During this period, he undertook a research stay at the University of Santiago de Compostela (Spain), where he participated in drug discovery studies focused on neurodegenerative diseases.
His postdoctoral research led to the development of fluorescent chemosensors with biomedical and environmental applications, securing funding through the VRIEA-PUCV project (2017) and a FONDECYT Postdoctoral Grant (3180408). These advancements contributed to sensitive detection methods for clinically relevant and environmental analytes. Subsequently, he was awarded the Installation in Academia Grant (77210078) at Universidad Central de Chile, where he currently serves as a researcher. His current research centers on the design of sensors and the application of computational methods to identify novel compounds with therapeutic potential, resulting in the proposal of candidate molecules for further bioactivity evaluation. He has established interdisciplinary collaborations in medicinal chemistry, natural product bioactivity, and fluorescent sensors, as reflected in his scientific publications and postgraduate teaching in QSAR-related courses.
Marco Mellado has served as a peer reviewer for more than 50 manuscripts in international indexed journals, including Natural Product Research, Medicinal Chemistry Research, Archiv der Pharmazie, ACS Omega, Molecules, and Frontiers in Pharmacology. In addition, Dr. Mellado has evaluated national and international research projects. He also has extensive experience in undergraduate and postgraduate teaching and is committed to the training of future scientists through thesis supervision and academic mentoring.
Research Interests
Organic synthesis driven by computational analysis
Dyes and pigments discovery and their photophysical properties
Fluorimetric and colorimetric chemosensors and their application on living cell imaging
Keywords
- J General legislative and executive papers
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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SDG 9 Industry, Innovation, and Infrastructure
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SDG 14 Life Below Water
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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DESIGN AND SYNTHESIS OF BENZOIC ACID DERIVATIVES AS TRPC6 CHANNEL AGONISTS: POTENTIAL DRUGS FOR THE TREATMENT OF AUTISM SPECTRUM DISORDERS
Mella, J. (PI) & Mellado Garcia, M. A. (CoI)
1/04/24 → 31/03/28
Project: Research
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EN LA BÚSQUEDA DE QUIMIOSENSORES FLUORESCENTES CATIÓNICOS: SÍNTESIS Y SU POTENCIAL APLICACIÓN NEUROLÓGICA A PARTIR DE DERIVADOS DE 2-AMINOPIRIMIDINA
Mellado Garcia, M. A. (PI) & Arteaga Manieu, M. (CoI)
1/01/22 → 31/12/24
Project: Research
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2-Aminopyrimidine derivatives as potential fluorescent chemosensors for trivalent cations: Structural characterization, photophysical properties, and live-cell imaging
Covarrubias, A. A., Cerda, D., Coddou, C., Saldías, M., Villaman, D., Sánchez-González, R., González-Díaz, J., Freire, R. M., Riquelme, M., Haase, A., Rodriguez-Prieto, F. & Mellado, M., 15 Jan 2026, In: Journal of Molecular Structure. 1350, 144119.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
3D-QSAR study for the development of chalcone-based inhibitors targeting ovarian cancer cells with experimental validation
Valenzuela-Valderrama, M., Varas, A., Rubilar, M., Lorca, M., Mella, J., Espinosa-Bustos, C., Mellado, M. & Echeverría, J., 9 Mar 2026, In: Frontiers in Pharmacology. 17, p. 1746658-1746676 1746658.Research output: Contribution to journal › Article › peer-review
Open Access -
Experimental and In Silico Studies to Unravel the Antioxidant and Antibacterial Properties of Lichen Metabolites from Pseudocyphellaria compar and Pseudocyphellaria nudata
Cuellar, M. A., Mejía, J., Quintero-Pertuz, H., Castro-Álvarez, A., Mellado, M., Vera-Quezada, W., Montenegro, G., Espinosa-Bustos, C., Bridi, R. & Salas, C. O., Jan 2026, In: Antioxidants. 15, 1, 34.Research output: Contribution to journal › Article › peer-review
Open Access -
Mapping Global Research Trends on Autism Spectrum Disorder: A Bibliometric Analysis of Pharmacology and Pharmacy Studies
Sabadini, G., Palacios-Muñoz, A., García, I. E., Romero-Parra, J., Moraga, D., Soto, M., Vega-Muñoz, A., Contreras-Barraza, N., Salazar-Sepúlveda, G., Mella, J. & Mellado, M., Jan 2026, In: Pharmaceuticals. 19, 1, 102.Research output: Contribution to journal › Article › peer-review
Open Access -
Benzo[d]imidazole–Naphthalen-Arylmethanone Regioisomers as CB1 Ligands: Evaluation of Agonism via an Indirect Cytotoxicity-Based Approach
Hwa Cho, A. Y., Burgos Ravanal, R., Zuñiga Salazar, V., Mellado, M., Lorca, M., Pessoa-Mahana, D., Mella, J., Günther Sapunar, G. & Romero-Parra, J., Oct 2025, In: International Journal of Molecular Sciences. 26, 20, 9986.Research output: Contribution to journal › Article › peer-review